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When receptor proteins on limbic system nerve cells are exposed to high levels of dopamine neurotransmitter molecules for prolonged periods of time, the nerve cells turn down the volume of the signal by lowering the number of receptor proteins on their surfaces

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Moyer TP, Charlson JR, Enger RJ, Dale LC, Ebbert JO, Schroeder DR, et al

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When contacted by a Washington Post reporter, however, the researchers refused to talk

It conveniently makes both king size and 100mm cigarettes