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This method can be particularly beneficial for those with deficiencies or absorption issues

When present, usually mild and transient

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This offers a direct reference for prostate cancer (PCa): in patients resistant to AR pathway inhibitors (e.g., abiraterone, enzalutamide), the LPA axis may serve as an analogous escape pathway. By activating non-classical AR signaling, LPA (unspecified species) drives castration-resistant PCa (CRPC)

Since nitrous oxide is commonly used for surgery in the elderly, some experts feel vitamin B 12 deficiency should be ruled out prior to its use or prophylactic vitamin B 12 supplementation implemented before and after exposure to the gas (7, 18)

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