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Responsibilities of Businesses Purchasing Tobacco in the United States The US is one of the top producers of unmanufactured tobacco in the world, behind China, Brazil, and India.[369] Approximately 5.8 trillion cigarettes are consumed around the world annually.[370] China is by far the largest market, accounting for nearly one-third of global consumption, but it is almost exclusively operated by a state monopoly, China National Tobacco

In one laboratory study, the chemicals that leached from a single cigarette butt (soaked for 24 hours in a liter of water) released enough toxins to kill 50 percent of the saltwater and freshwater fish exposed to it for 96 hours

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We extracted 51 observations from 11 prospective cohort studies and 4 casecontrol studies across 36 locations (Supplementary Table 3) 6,8,9,10,78,108,109,110,111,112,113,114,115,116

Nicotine is also linked to impaired lung function when inhaled and nausea, abdominal pain, and increased risk of gastrointestinal disorders

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