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Maher Karam-Hage, a tobacco treatment expert and addiction specialist at the University of Texas MD Anderson Center, explained in a center article

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Effects of polystyrene nanoplastic gestational exposure on mice

Acute toxicity from cannabis exposure mostly consists of excessive sedation, loss of coordination, rapid heart rate, and dilated pupils

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But considering the already accessible price point, that premium for the cartridges might be a worthy tradeoff