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As a result, the methylation cycle will be compromised or impaired, along with many other functions that depend on it, including glutathione production

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The SLC2A1 transcript is one of the most abundant transcripts in brain endothelium, and SLC2A1 dysfunction or reduction can severely affect BBB integrity and cognitive function in mice 82-84 and humans

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Lets take a look at a few animal studies as examples: Adding stress hormones causes mitochondrial dysfunction: The addition of corticosterone in mice will cause depression, and this is one way of making a mouse model of depression

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