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These factors can discourage quitting

Smoking cigarettes can damage the heart, blood vessels, and blood cells

It might contribute to throat irritation if any free benzoic acid is present (benzoic acid is a mild irritant at higher concentrations)

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Every attempt to quit will make you stronger, and your odds of success increase with each attempt

Nicotine facilitates increased dopamine in the cortex similarly to observations in subcortical regions in that the drug binds high-affinity nAChRs on dopamine neurons that project from the VTA, but in this case toward the cortex, and binds low-affinity receptors on excitatory glutamatergic neurons projecting toward the prefrontal cortex (99, 100)