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(2022) examined the effects of human-specific, APOE4-driven lipid metabolic regulation
Cp1D could also amidate the terminal carboxylate of l-Asp-l-Phe, l-Asp-l-Leu and glutaryl-l-Leu with moderate activity to form isopentyl amidated dipeptides (Supplementary Fig
Ferroptosis triggers can be divided into those that act through the cystine/glutamate antiporter system, such as erastin, and those that act by inhibiting the activity of glutathione peroxidase, such as Ras Selective Lethal 3 [73, 74]
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These three compounds also exhibited more potent or comparable inhibitory activities to that of 1 toward cathepsins L and K, demonstrating that these act as pan-cathepsin inhibitors rather than selective inhibitors (Supplementary Fig
