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This aberrant immune response is characterized by airway eosinophilia, goblet cell hyperplasia, airway wall remodeling, and production of allergen-specific IgE, all driven by T helper (Th)2-derived cytokines, such as interleukin (IL)-4, IL-5, and IL-13

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Several studies have shown that e-cigarettes increase PWV in humans (185)

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Scroll down to see Johns biggest health ups and downs over the years: 1975 John began his battle with addiction while rising to fame in the 70s and 80s