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The UK plain packaging legislation for cigarettes comes into effect in 2016, and requires that tobacco packets be of uniform size, shape and design, featuring only brand name and graphic health warnings

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What Happens When You Smoke

Comprehensive genomic analyses have revealed a distinct tobacco-related mutational signature in liver tumors of smokers, characterized by cytosine-to-adenine base substitutions, dinucleotide alterations, and guanine adduct formation, patterns resembling those observed in lung and head-and-neck cancers [38,39,40]

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These compounds result from incomplete combustion of the organic matter of the cigarette, most notably sugars and cellulose (Chortyk and Schlotzhauer 1973)