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Though it can be distressing, especially when episodes become frequent or severe, they usually arent harmful

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The NP showed similar nicotine bioavailability to the lozenge ( p = 0.6526 (C max ), p = 1.0000 (AUC 0-T )), and superior bioavailability to the gum ( p 6 mg ISO tar) per day for at least 6 months

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Hemoglobin has a high affinity for CO and once bound, the new molecule (carboxyhemoglobin [COHb]) is no longer capable of binding oxygen