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Nicotine dependence among adult smokers is characterized by the emergence of withdrawal symptoms in response to abstinence and by unsuccessful attempts to reduce the use of tobacco or to quit altogether (Fiore et al

The body takes a long time to clear carbon monoxideup to a day

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It has been suggested that the mode of action of bupropion and nortriptyline could be independent of their antidepressant effect, and that their efficacy is similar to that of nicotine replacement[61]

doi: 10.1111/add.13636 [DOI] [PMC free article] [PubMed] [Google Scholar] 18.Kaplan BA, Koffarnus MN, Franck CT, Bickel WK

Retrieved 9 March 2018