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Sorafenib [a small-molecule multi-kinase inhibitor that targets vascular endothelial growth factor receptors (VEGFRs) rapidly accelerated fibrosarcoma (RAF) and other protein kinases] has been regarded as the standard of treatment for patients with advanced HCC since 2007 ( Tivantinib, a staurosporine derivative, is a non-ATP competitive selective small-molecule inhibitor and acts mainly as an anti c-Met inhibitor (Santoro et al., 2013)
Additionally, a competition for iron between the two entities exits, as iron is vital for both and is also implicated in macrophage defensive oxidative mechanisms and modulation of their phenotype
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