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The data from Table 1 is derived from a three-way cross-over study of repeated applications of NICOTROL NS in sixteen smokers (8 male, 8 female) ranging in age from 18 to 48 years

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When BH 4 is oxidized, eNOS uncoupling is equal with a reduction of NO production and starting the production of a superoxide radical instead, scavenging more NO and oxidizing more BH 4 , thus propagating the vicious cycle [42]

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