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Int J Biol Macromol 164:42894298 Acknowledgements The authors would like to acknowledge the Research Center for Environmental Health Technology, Iran University of Medical Sciences, Tehran, Iran, for supporting and funding this research (Grant Number: 98-2-2-15471)

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The cigars were rolled in the newly established El Laguito factory in Havana, which had been established to roll Cuban President Fidel Castro's own personal cigars, named Cohba