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In addition to these black box warnings, the FDA states that pregnant women at 20 weeks or later should avoid taking any NSAIDs because it can affect proper development of their unborn baby's kidneys

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These previous studies [12,13,14,15,16,17] had several limitations such as the inclusion of relatively small number of cases, especially for rare type of congenital anomalies (i.e., being underpowered to detect small or moderate risk effect), the use of case-control design (i.e., being more prone to selection bias), or insufficient adjustment for potential confounders (i.e., being more prone to confounding bias)

Bernays realised, as he recalled decades later: If this [propaganda] can be used for war, it can be used for peace. Short of stature, with a thick black moustache, Bernays was one of the fledgling PR industrys most controversial figures