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Nationwide, 17 percent of students had taken prescription drugs (e.g., Oxycontin, Percocet, Vicodin, codeine, Adderall, Ritalin, or Xanax) without a doctors prescription one or more times during their life

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That variability shows how much context matters in the nicotine and dopamine story

Psychological Distress: Anxiety, panic attacks, paranoia, and hallucinations are common even after a single use