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To test if Akt acted on Bcl-2 phosphorylation, and was responsible for nicotine-mediated increase of Bcl-2 stability, various kinase inhibitors were added to H5800 or LKR cell cultures, before the cotreatment of nicotine and cisplatin

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This is where the craving part of the addiction comes into play

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These findings might seem surprising but there are a number of studies linking musculoskeletal disorders with smoking 10-13 and diabetes with SHS 30-31