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Possibly fashion, in its journey from east to west, left certain phrases and metaphors behind, which being annexed by the newcomers, sank gradually in the social scale until they ultimately passed out of the written language altogether, and became flash or Slang
It all started when Cardinal Prospero Santacroce, who was the papal nuncio to both Portugal and France, met Jean Nicot, France's ambassador to Portugal, in Lisbon in 1561
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Other clinical types of leukoplakia were also reported to show positive telomerase activity with a rate of 31% in moderate to severe dysplasia, 44% in ulcerated and nodular, and 36% in verrucous leukoplakia (Thomas et al., 2020)
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