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In mammals, PGC-1 plays a primary role in regulating mitochondrial biogenesis (Ding et al., 2021)

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Specifically, data on mortality and disability-adjusted life years (DALYs) for dementia (ICD-10 codes: F00-F03, G30-G31) and multiple sclerosis (ICD-10 code: G35), along with their corresponding 95% uncertainty intervals (UIs), were extracted from the GBD 2021