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First, previous studies have documented the adverse effect of tobacco smoke exposure on nasal physiology and function by impairing mucociliary clearance 24 , reducing nasal volume 25 , and increasing nasal airway resistance 26

Historically, it was cultivated primarily in Thrace and Macedonia, now divided among Greece, Bulgaria, the Republic of Macedonia, and Turkey, but it is now also grown on the Black Sea coast of Turkey, in Egypt, in South Africa, and elsewhere

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And, also like wines, different blends have different life-expectancies before they go "over the hill." Biological and chemical processes begin to take place as soon as a tobacco is tinned, and the changes can be dramatic, depending on the blend itself, how long its left to sit, and the conditions under which its aged

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