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In the non-treatment extension of the postmarketing neuropsychiatric safety outcomes trial that assessed CV safety (8), the most common adverse events in subjects treated with varenicline and occurring up to 30 days after last dose of treatment were similar to those observed in premarketing studies

Mitral valve prolapse (MVP), resulting from redundant chordae tendineae and valve cusps, has been reported, most often with hypermobile and vascular EDS [68]

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The researchers found that arterial health improved over with time once smokers quit, but only reached normal levels after more than a decade of abstinence