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The drive to smoke may be more tied to external stimuli (e.g., social cues) rather than the need to maintain steady nicotine levels to avoid withdrawal

A combination of nicotine with weak organic acids to form nicotine salts has also been applied in pharmaceutical formulations used in Metered Dose Inhalers (MDIs) therapy equipment 28

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Recent studies of smoking-related health problems and memory deficits has included the effects of second-hand or passive smoking, where non-smokers inhale tobacco smoke from smokers