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This is a novel approach, but it has not been the bread and butter of tobacco control, he said

Cells that increase rapidly pick up more mistakes in their DNA, which can eventually turn into cancer

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Tobacco smoking reduces p53, a tumor suppressor gene that is considered the genome guardian. Suppression of T-cell responses by Nicotine and tar is associated with decreased surveillance for tumor cells] reported that heavy smokers accumulate excess iron in hepatocytes which induces fibrosis and favors the development of HCC

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