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Briefly, human in vitro systems do not reflect all aspects of cellular interaction and tissue organization, in vivo animal models do not necessarily reflect human biology in its finer details, and human clinical studies are hampered by time and cost constraints as well as accessibility to key biological samples (that are accessible in animal studies)

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flyers, social media) and, during the pre-COVID period in New York, by using intercept recruitment methods at smoke-shops in low-income neighborhoods 10,22

E-cigarettes have become increasingly popular over the last few years, no doubt in part down to prominent promotional campaigns from manufacturers

When even one element is removed, combustion stops

For the purpose of analysis, ex-smokers were coded as non-smokers