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Retrieved 7 April 2016

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As early as the 1970s, Tobacco Mosaic Virus (TMV) was shown to possess substantial interferon-inducing and antiviral activity in mammalian systems, comparable to synthetic interferon inducers, despite its inability to replicate in vertebrate cells ( Consistent with this framework, prophylactic induction of interferon responses can reduce susceptibility to SARS-CoV-2

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