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A shot of Fernet is described, in the Summit Sips post and elsewhere, as the "bartender's handshake," a sort of secret signal that you're in the club, you know your stuff, you're a real aficionado

Cancer patients who continue smoking or using tobacco after diagnosis experience significantly worse outcomes, including increased tumor progression, higher rates of developing a second cancer, greater recurrence following treatment, and increased cancer-related mortality

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You want to talk to your doctor or pharmacist to make sure that if youre going to use nicotine, its not interacting with other drugs to cause harmful effects. The question is whether nicotine biohacking is the latest longevity gimmick with potential harms, or if it has legitimate benefits for brain health