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Answer: The answer depends on personal needs and the specific medical condition in question

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So if experience tells you that caffeine keeps you awake (caffeine blocks the effect of adenosine on the brain - read here about adenosine and sleep) our suggestion is to have your last coffee just after lunch for a better nights sleep (and watch the total amount of caffeine you consume)

Now, we know quite a lot about nicotines effects and the possibility of dependenceespecially pertaining to cigarettes

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