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Both SIRT1 and SIRT2 are reported to deacetylate the RelA / p65 subunit of NF - at lysine 310, inhibiting NF - signaling, while SIRT6 has been shown to interact with the p65 / RelA that is bound to the NF - promoter region to repress transcriptional activity, which results in reduced expression levels of inflammatory factors [144]

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OCLC 818916146