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After investigating the cause, an update for tomorrow morning (July 7th, 2026) is planned for reproducing and fixing the root cause
Concerning CYP1A2, in vivo induction is suggested, as demonstrated by the paraxanthine-to-caffeine ratio rising in healthy subjects ( In light of these findings, the safety and efficacy profile of RIF during TB treatment can be altered in smokers because of the concomitant induction of CYP450 enzymes mediated by PAHs
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