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(2014) 23:iii39

Cytochrome P450 2A13 (CYP2A13), an extrahepatic enzyme mostly expressed in the human respiratory system, has been discovered to mediate cigarette smoke metabolism and toxicity

So theres all these weird little things in there

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Steven Mesquiti of Princeton University

Moxibustion is not recommended for individuals with high fever, lung conditions like asthma, lymphedema, low white blood cell count, heart murmurs, or those with implanted cardiac devices