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[106] Adolescents are more likely to become nicotine dependent than adults

4 Effects on Organ Systems Cardiovascular System Nicotines effects on peripheral chemoreceptors include increased adrenaline secretion from the adrenal medulla, direct stimulation of the carotid and aortic bodies, and increased sympathetic tone from the autonomic ganglia

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(PMC) Nicotine metabolism: Pharmacokinetic studies show nicotine and cotinine clearance is higher in women than men

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The harmful chemicals in cigarette smoke can damage the DNA in skin cells, impairing their ability to function properly and increasing the likelihood of mutations that can lead to cancerous growths