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If this happens, remove the pouch right away

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Proceedings of the Human Factors and Ergonomics Society Annual Meeting

Other less common reasons for GERD are the lack of saliva or the loss of the esophageal squeeze that can delay the clearing of acid from the esophagus

Cardiovasc Toxicol 15:107116 Asano H, Horinouchi T, Mai Y, Sawada O, Fujii S, Nishiya T, Minami M, Katayama T, Iwanaga T, Terada K, Miwa S (2012) Nicotine- and Tar-free cigarette smoke induces cell damage through reactive oxygen species newly generated by PKC-dependent activation of NADPH oxidase