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Small amounts of nicotine act as a muscle relaxer, however it is also known to increase heart rate and blood pressure

This compensatory mechanism may help alleviate COPD symptoms and delay disease progression

Supporting this view, the relation of stroke index to aortic reflection time was higher in present smokers than in never smokers both supine and upright (0.334 0.007 versus 0.314 0.03 ml/m 2 /ms, p = 0.009

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