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Tolerance develops because your brain adapts to constant receptor stimulation, you cant reverse this while maintaining exposure

Even just a 1/4 lb would last me for a year and then some, I'd imagine, but again, I'm not a heavy tobacco smoker, so your mileage may vary

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So if baseline air pollution in DC is 10 and its currently 160, the increased risk of heart attacks is close to 40%

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However, it significantly slows the progression of COPD and helps protect the remaining lung function