In total, we tested 57,002 alternative splicing events (16,704 skipping exons, 1142 mutually exclusive exons, 6491 alternative 5 splice sites, 7412 alternative 3 splice sites, 3919 intron retentions, 16,681 alternative first exons, and 4653 alternative last exons) across tissues
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Nuclearcytoplasmic fractionation Nuclear and cytoplasmic fractions were isolated using the NE-PER extraction kit
The 36 health outcomes that were selected based on existing evidence of a relationship included 16 cancers (lung cancer, esophageal cancer, stomach cancer, leukemia, liver cancer, laryngeal cancer, breast cancer, cervical cancer, colorectal cancer, lip and oral cavity cancer, nasopharyngeal cancer, other pharynx cancer (excluding nasopharynx cancer), pancreatic cancer, bladder cancer, kidney cancer and prostate cancer), 5 cardiovascular diseases (CVDs: ischemic heart disease, stroke, atrial fibrillation and flutter, aortic aneurysm and peripheral artery disease) and 15 other diseases (COPD, lower respiratory tract infections, tuberculosis, asthma, type 2 diabetes, Alzheimers disease and related dementias, Parkinsons disease, multiple sclerosis, cataracts, gallbladder diseases, low back pain, peptic ulcer disease, rheumatoid arthritis, macular degeneration and fractures)
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