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An increase in mitochondrial ROS level was measured in nicotine-treated HT29 adenocarcinoma cells, and this increase was abolished by rotenone and myxothiazol (complex I and complex III inhibitors, respectively), indicating that ROS originated from the respiratory chain (Pelissier-Rota et al

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Nicotine is highly addictive and can harm adolescent brain development, which continues into the early to mid-20s (CDC)

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In a US cohort of 554 adult smokers, 87% reported withdrawal symptoms after not smoking for 1 week and two-thirds reported craving ( It is interesting to note that among Chinese ever-smokers, only 11% are ex-smokers, while among ever-smokers in Western countries such as UK and USA, over 60% are ex-smokers ( Among individual withdrawal symptoms, the high occurrence of anxiety was unexpected