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Specifically, a Ka/Ks ratio of 1 indicates neutral selection, a ratio greater than 1 signifies positive selection accompanied by accelerated evolution, and a ratio less than 1 suggests purifying selection under functional constraints [75]

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5,55 However, recent studies have shown that the depletion and inhibition of the further recruitment of macrophages into the lungs significantly impede metastasis, although this is not mechanistically understood