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They possess three domains: a RING1 domain that binds to Ub-loaded E2, a RING2 domain that catalyzes a transthioesterification reaction with a cysteine residue and receives ubiquitin from RING1, and an in-between-RING (IBR) domain 15

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But in these next two stages, they are no longer in control

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Examples of distraction could include: Handling the device (refilling, adjusting settings) takes your hands off the wheel or your eyes off the road