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The aim of our study was to determine the impact of tobacco and cannabis on sperm quality, sperm DNA integrity tested by Chromomycin A3 (CMA3) and acridine orange (AO) and their association to genetic variants in the Cytochrome C Oxidase 1, 2 and 3 genes ( MT-CO1 , MT-CO2 , and MT-CO3 )

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In the 2026 study, Cuttler and her co-author randomly assigned 120 cannabis users to vaporize a placebo or doses of THC (20 or 40 milligrams)