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[181] E-cigarette advocates stated filing US FDA applications is too expensive for small companies, which will give consumers less options because it is expected only large tobacco companies can afford the steep costs

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Nonetheless, the evidence is still conflicting

I will try anything but commercially marketed products given a choice

Also observed a significant increase in cytochrome P450 (CYP)-CYP1A1/2, CYP2B1/2 and CYP3A to an enhanced cancer risk from the widely bioactivated e-cig vapour procarcinogens associated with an increased risk of lung cancer with CYP induction and/or CYP polymorphisms (Table 3)