Nicotine is not a conventional carcinogen, but was able to induce the secretion of growth factors, resulting in the activation of Raf, Akt or PKC pathways to promote the growth of various epithelial or cancer cells (Rakowicz-Szulczynska et al, 1994
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doi: 10.1515/cerce-2017-0015 13 FengW.Snchez-RodrguezA
Numerous epidemiological studies have demonstrated that former smokers have a substantially lower risk than current smokers, reflecting the bodys ability to repair some of the damage caused by tobacco carcinogens once exposure ceases
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