Further analyses and interpretation regarding the geographical patterns, potential country-level indicators, and a possible second mediator related to the sub-clusters are provided in Supplementary materialAppendix F
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BV is characterized by the loss or sharp decline in the total number of Lactobacillus and a corresponding 1001000 fold increase in the concentration of facultative or obligate anaerobic microbes, such as Gardnerella, Prevotella, Atopobium, Mobiluncus, Bifidobacterium , Sneathia, Leptotrichia , and some novel bacteria in Clostridiales order referred to as BV-associated bacteria (BVAB) 13 (Fredricks et al., 2005
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