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However, therapeutic strategies targeting this axis continue to face multiple challenges, including limited availability of validated targets, substantial disease heterogeneity, fragmentation of current intervention approaches, and the pressing need to shift from localized symptom control toward comprehensive restoration of systemic immune and neurophysiological homeostasis

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Among them are Charles Bronson, sex killer Graham Coutts and Roy Whiting, who killed eight-year-old Sarah Payne in 2000

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