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Participants were selected randomly from local registries stratified by age and sex, with a higher proportion of participants aged 40 and above since the incidence of many investigated diseases within the NAKO peaks beyond the age of 40 [26]

Tobacco was recognised as a medicine soon after it was first imported from the New World, and tobacco smoke was used by Western medical practitioners as a tool against cold and drowsiness, but applying it by enema was a technique learned from the North American indigenous peoples

However, it was not until 2003 that the first commercial device was created in Beijing by a pharmacist

The hard work has paid off

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