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However, these bulk expression changes are a composite of all cell type gene expression changes, cell frequency shifts, and emergent metaplastic cell states, making it impossible to determine the precise cellular and molecular changes induced by smoke exposure using this type of expression data

When these chemicals are burned, they release highly toxic compounds like Dioxins and Furans, which are known to cause cancer, endocrine disruption, and immune system failure

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The most common cause is cigarette smoking

Breathing the toxic chemicals in cigarette smoke harms nearly every organ in your body