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Jan 1;75(1):10.1016/j.biopsych.2013.02.024 Biddinger KJ, et al

Sayre said hes been told by suppliers and others in the tobacco industry that much of the Maryland variety being grown in the U.S

By overriding the normal system used by the brain to coordinate its many activities, nicotine alters the pattern of release into gaps between nerve cells of many neurotransmitters, including acetylcholine, dopamine, serotonin and many others

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The most important, however, is that it offers the enjoyment of real tobacco that is heated, not burned: No ash, no cigarette smoke, and no persistent smell