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Am J Health Syst Pharm

Figure 2 The core characteristics and mechanisms of candidalysin are well-defined: it exerts cytotoxicity by membrane insertion/lytication, activates pathways such as EGFR-MAPK and NLRP3 inflammasome to induce inflammation and damage in host cells, and targeted anti-infection strategies against this toxin have been summarized (Lortal et al., 2025)

The review found that oral and topical formulations demonstrate significant but variable melanin reduction with minimal side effects, while intravenous glutathione carries serious safety concerns including anaphylaxis and hepatotoxicity

For instance, the HFD model primarily induces fat accumulation and insulin resistance, while the MCD model results in more pronounced hepatic fibrosis

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461 During regeneration, TRIB1 downregulation permits NRF2 nuclear translocation, activating antioxidant response and fostering a conducive environment for hepatocyte proliferation