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These labels expanded beyond a simple warning to address the very specific ways tobacco smoke harms the body, including risks to children exposed to secondhand smoke

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[51] Aromatase excess syndrome is a rare genetic disorder that leads to increased conversion of androgens to estrogens in the body

Age is the most often cited risk factor

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The adjusted frequencies for current symptoms and lifetime diagnosis were 4.0% for individuals who never smoked (CI [3.9%,4.1%]), 5.6% for those who formerly smoked (CI [5.5%,5.7%]), and 8.7% for those who currently smoked (CI [8.5%,8.8%]) (Fig