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Depending on the size of the inhaled complex smoke particles, they can be deposited throughout the airway

J Rheumatol 30 : 12221226 Washio M et al

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Molecular epidemiology studies, in particular of the TP53 , KRAS and epidermal growth factor receptor ( EGFR ) genes, demonstrate strikingly different mutation patterns and frequencies between lung cancers in never smokers and smokers