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It operates by modulating GABA neurotransmitter activity and influencing gene expression related to memory and immune response.

Tissues were immersion-fixed in 4% paraformaldehyde in 0.1 M phosphate buffer (pH 7.4) for 24 h at 4 C, dehydrated through graded ethanol, cleared in xylene, and embedded in paraffin

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According to the two-hit model, the initial phase, often referred to as the first hit, involves the build-up of fat, specifically triglycerides, within the liver tissue and the development of insulin resistance

Traumatic brain injury: neuropathological, neurocognitive and neurobehavioral sequelae